Diagnosing and Battling Acute Myelogenous Leukemia (AML)

Jul, 2014

Diagnosing and Battling Acute Myelogenous Leukemia (AML)

  • Posted on July 24, 2014 by Pharma Models Blogging Team in Oncology

Leukemia is cancer of white blood cells known to take the lives of 24,000 patients every year in the United States. There are many different types of leukemia, reflecting the diversity of the different types of white cells found in the human body and the different ages at which leukemia can develop. The most common […]

Jul, 2014

The Importance of Mouse Models in Liver Cancer Research

  • Posted on July 14, 2014 by Pharma Models Blogging Team in Oncology

No human diseases have been cured without the assistance of animal research. Mouse models in particular have advanced pre-clinical studies and improved the outcome of a variety of serious medical conditions. Liver cancer is one malignancy with a high mortality rate, but animal research has enhanced the health outcomes of patients with this disease. One […]

Jun, 2014

TCL1 Transgenic Mice and T-Cell Dysfunction in Chronic Lymphocytic Leukemia

  • Posted on June 17, 2014 by Pharma Models Blogging Team in Oncology

Understanding the TCL1 oncogene has provided valuable insights for gaining a better understanding of the causal relationship between leukemia and T-cell defects of the immune system. Altered pathways and malignant transformations activated by mutation within the TCL1 oncogene in patients are accurately represented by the TCL1 transgenic mouse model. This animal model has been widely validated […]

May, 2014

Four Tumor Models Vital in Our Search for a Cancer Cure

  • Posted on May 26, 2014 by Pharma Models Blogging Team in Oncology

Many early steps in cancer research began in either animal or tumor models. Without these prototypes, researchers would not have been able to create effective drug treatments or find a cure. In the 1960s, the earliest in vivo tumor models were developed, which were ascites models or murine leukemia models. A paper published in the […]

May, 2014

Comparing Mouse Xenograft Models and Genetically Engineered Models

  • Posted on May 21, 2014 by Pharma Models Blogging Team in Oncology

Murine models have served as a mainstay for preclinical cancer research trials for many decades, and continue to provide important insight into factors that influence malignant transformation of a tumor, tumor rate of growth, metastatic disease, and other activities. Two of the most widely used models include the mouse xenograft model and the genetically engineered […]

May, 2014

Animal Testing Significantly Advances Cancer Research

  • Posted on May 13, 2014 by Pharma Models Blogging Team in Oncology

Today, patients who are diagnosed with cancer have a much higher likelihood of survival than in decades past. Fifty or sixty years ago, cancer was nearly always assigned a death sentence. Scientific cancer research, however, has brought effective treatments and increased the lifespan of most cancer patients. The advances that we have seen would not […]

May, 2014

Welcome to the New Pharma Models Blog

The design of pre-clinical studies is a complex task, and understanding the translation from animal model to human diseases requires a great deal of care and a high level of understanding of both the basic science and the clinical condition. Many drugs in clinical development flounder due to lack of efficacy or unacceptable side effects. […]