The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

30
Jun, 2014

The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]