Cell Culture Methods and Xenografts for Modeling Breast Cancer Metastasis in Early Drug Discovery

18
Dec, 2014

Cell Culture Methods and Xenografts for Modeling Breast Cancer Metastasis in Early Drug Discovery

  • Posted on December 18, 2014 by Pharma Models Blogging Team in Oncology

Approximately 75% of breast cancers are diagnosed as hormone positive and exhibit acceptable responses to endocrine-targeted therapies, whereas 7-15% are ER-/PR- Her2+ or ER-/PR-/HER2- – which are somewhat refractory to conventional endocrine treatment. Gene variations, different cancer subtypes, and diverse histopathologies and clinical outcomes among patients all present a challenge to currently available breast cancer […]