Pharma Models Pre-Clinical Research Blog

28
Jul, 2014

The Breast Cancer Drug Market Shoots for the Stars

  • Posted on July 28, 2014 by Pharma Models Blogging Team in Oncology

Breast cancer is a difficult diagnosis to receive for any woman, as this disease leads to approximately 40,000 deaths in the United States every year. Breast cancer also affects about one in eight women throughout a lifetime. The healthcare sector and cancer drug market has focused on developing better treatments over the years, which has […]

24
Jul, 2014

Diagnosing and Battling Acute Myelogenous Leukemia (AML)

  • Posted on July 24, 2014 by Pharma Models Blogging Team in Oncology

Leukemia is cancer of white blood cells known to take the lives of 24,000 patients every year in the United States. There are many different types of leukemia, reflecting the diversity of the different types of white cells found in the human body and the different ages at which leukemia can develop. The most common […]

23
Jul, 2014

High-Throughput Screening Methods in Drug Discovery

Advanced methods of combinatory chemistry have made it possible to quickly synthesize vast quantities of compounds for testing. These compounds are then tested in a rapid method of evaluation called high-throughput screening. High-throughput screening (HTS) allows researchers to  quickly and cost-effectively process thousands and even hundreds of thousands (ultra-high-throughput screening, or uHTS) of compounds, which […]

17
Jul, 2014

Antibody Engineering for Creating Novel Biopharmaceutical Products

  • Posted on July 17, 2014 by Pharma Models Blogging Team in Immunology

Antibodies (Ab), or immunoglobulins (Ig), are naturally occurring proteins found in great abundance in our bodies. They are used by the immune system to identify and subdue antigens, or foreign substances that are found in the body which may cause disease or infection. Antibody engineering is a powerful resource for creating novel biopharmaceuticals. The most […]

14
Jul, 2014

The Importance of Mouse Models in Liver Cancer Research

  • Posted on July 14, 2014 by Pharma Models Blogging Team in Oncology

No human diseases have been cured without the assistance of animal research. Mouse models in particular have advanced pre-clinical studies and improved the outcome of a variety of serious medical conditions. Liver cancer is one malignancy with a high mortality rate, but animal research has enhanced the health outcomes of patients with this disease. One […]

10
Jul, 2014

Sufficient Early ADME Profiling to Minimize Wasted Time and Expenditures

The development process of new therapeutics is one of several factors that directly impact the cost of healthcare today. Due to the amount of time and money involved, great efforts are being made to change the way drug candidates are processed, evaluated and selected. While certain processes were once approached as the next step of […]

08
Jul, 2014

Examining Human Obesity on a Molecular Level Using Murine Models of Obesity

  • Posted on July 08, 2014 by Pharma Models Blogging Team in Obesity

Over twenty years ago, the agouti mouse was the first model cloned from which an obesity gene was described. Mutations in the agouti gene are associated with variations in coat color (stripes in cats and tigers), when an animal carries a single copy (or allele) of the gene. When the animal is homozygois for the […]

03
Jul, 2014

Computer Modeling Useful for Planning a Drug Trial

Until recently, the clinical research sector has had difficulty adopting computer modeling and simulation due to a variety of factors. Among these have been, the uncertain regulatory challenges of modeling and simulation applications, a lack of large-population data, and complicated biological systems. These factors have all prevented the utiliziation of computer modeling. However, these barriers […]

02
Jul, 2014

Animal Models of Inflammatory Disease Provides Pathogenic Insight

Inflammatory bowel diseases (IBD) are autoimmune conditions in which the immune system attacks regions of the digestive system. Crohn’s disease (CD) and ulcerative colitis (UC) are the two most common forms of IBD, differing in nature and location of inflammation within the digestive system. Although there are notable differences between CD and UC – which […]

30
Jun, 2014

The Role of Drug Metabolism and Pharmacokinetics in Lead Discovery and Optimization

The goal of lead optimization within the discovery phase of drug development is a multifaceted process, drawing from various compound properties to hone in on analogs that demonstrate the strongest potential for targeted therapies. Drug metabolism and pharmacokinetic (DMPK) property assessment is crucial to achieving desired biological activities and for determining safety profiles. DMPK data […]

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